ABSTRACT
Thyroiditis is one of the manifestations of novel Covid-19 virus. Thyroid function test (TFTs) shows typical features of hyperthyroidism. Inflammatory markers and thyroid scan give clue to the diagnosis. This report is about a 39-year-old female who presented with signs and symptoms of thyrotoxicosis along with pain in the neck, odynophagia, and intermittent fever after recovering from Covid-19 a few weeks back. She had no significant history of past medical or endocrine disease. TFTs revealed high T3 and T4 and low TSH. Thyroid scan revealed decrease uptake and ESR was 115. She was started on NSAID, steroids, and beta blocker. Four weeks later, she reverted with the resolution of symptoms and normal TFTs.
Subject(s)
COVID-19 , Hyperthyroidism , Thyroiditis , Thyrotoxicosis , Female , Humans , Adult , Hyperthyroidism/diagnosis , Thyroiditis/diagnosis , Thyrotoxicosis/chemically induced , Thyroid Function Tests , PainABSTRACT
A euthyroid woman in her 50s with papillary thyroid cancer and primary hyperparathyroidism was referred to our hospital for surgery. Her surgery was scheduled for 4 months later but was postponed because she was diagnosed with COVID-19. Five months after the first visit, she was admitted to our hospital to undergo the planned thyroid lobectomy and parathyroidectomy. Her blood tests on admission showed thyrotoxicosis, with negative thyroid-stimulating hormone receptor and thyroid-stimulating antibody. Notably, her anti-thyroglobulin antibody and anti-thyroid peroxidase antibody, which were originally negative, became positive after SARS-CoV-2 infection. She was diagnosed with painless thyroiditis. Her general condition and vital signs were stable, and the surgery was cautiously performed. Histopathological examination of the resected thyroid revealed papillary thyroid carcinoma, and the findings were consistent with painless thyroiditis. Her postoperative course was uneventful, and her thyroid function improved 2 weeks after the operation.
Subject(s)
Autoimmune Diseases , COVID-19 , Thyroid Neoplasms , Thyroiditis , Female , Humans , SARS-CoV-2 , Thyroiditis/diagnosis , Thyroid Cancer, PapillaryABSTRACT
PURPOSE: It is well established that thyroiditis and other thyroid disorders can be induced by COVID-19 infection, but there is limited information about the autoimmune/inflammatory syndrome induced by adjuvants (ASIA) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. We report two cases of thyrotoxicosis following SARS-CoV-2 vaccine. METHODS AND RESULTS: Two young health care peoples (wife and husband) received a first dose of SARS-CoV-2 vaccine, and few weeks later developed clinical manifestations of thyroid hyperactivity, with increased thyroid hormone levels on thyroid function tests, suppressed thyroid-stimulating hormone and negative antithyroid antibodies, despite being healthy before vaccination. They were diagnosed at the 4th week after first dose of SARS-Cov-2 vaccine as silent thyroiditis and followed without treatment, since their symptoms were not severe. At the 6th week, the patients became wholly asymptomatic and their thyroid function returned to normal. CONCLUSIONS: Thyrotoxicosis can occur after SARS-CoV-2 vaccination probably related to silent thyroiditis.
Subject(s)
COVID-19 , Thyroiditis, Autoimmune , Thyroiditis, Subacute , Thyroiditis , Thyrotoxicosis , COVID-19/prevention & control , COVID-19 Vaccines/adverse effects , Humans , SARS-CoV-2 , Thyroiditis/diagnosis , Thyroiditis/etiology , Thyroiditis, Subacute/diagnosis , Thyroiditis, Subacute/etiology , Thyrotoxicosis/diagnosis , Thyrotoxicosis/etiology , Vaccination/adverse effectsABSTRACT
Subacute thyroiditis following vaccination is an uncommon presentation of thyrotoxicosis. As the world undertakes its largest immunisation campaign to date in an attempt to protect the population from COVID-19 infections, an increasing number of rare post vaccine side effects are being observed. We report a case of a middle-aged woman who presented with painful thyroid swelling following the second dose of the COVID-19 mRNA vaccine BNT162b2 (Pfizer-BioNTech) with clinical, biochemical and imaging features consistent with destructive thyrotoxicosis. Symptomatic management only was required for the self-limiting episode. Thyroiditis typically has a mild and self-limiting course and thus this observation should not deter people from vaccination, as COVID-19 infection has a far greater morbidity and mortality risk than thyroiditis.
Subject(s)
COVID-19 , Thyroiditis, Subacute , Thyroiditis , BNT162 Vaccine , COVID-19 Vaccines , Female , Humans , Middle Aged , SARS-CoV-2 , Thyroiditis/chemically induced , Thyroiditis/diagnosis , Thyroiditis, Subacute/chemically induced , Thyroiditis, Subacute/diagnosisSubject(s)
COVID-19 Vaccines/adverse effects , Thyroiditis/chemically induced , Thyrotoxicosis/chemically induced , Vaccination/adverse effects , Autoantibodies/blood , BNT162 Vaccine , Biomarkers/blood , Female , Humans , Middle Aged , Risk Factors , Thyroid Hormones/blood , Thyroiditis/blood , Thyroiditis/diagnosis , Thyroiditis/immunology , Thyrotoxicosis/blood , Thyrotoxicosis/diagnosis , Thyrotoxicosis/immunologyABSTRACT
PURPOSE: To describe a case of acute thyroiditis and bilateral optic neuritis associated with SARS-CoV-2 vaccination. METHODS: A single case report from a tertiary referral center. RESULTS: The patient described in the following case report developed acute thyroiditis and bilateral optic neuritis following SARS-CoV-2 vaccination. The patient underwent pulse therapy followed by oral tapering corticosteroid therapy with an improvement of the bilateral disc swelling and the visual field, and recovery of thyroid-stimulating hormone to the normal limits. CONCLUSION: Although the association between immunization and the onset of demyelinating manifestations of the central nervous system is well documented, this is the first reported case of bilateral optic neuritis and acute thyroiditis and subsequent to administration of vaccination against SARS-CoV-2.